Opportunity Information: Apply for CDC RFA GH19 1922
The grant opportunity titled "Combination Prevention Solutions to Reach Epidemic Control among High Risk, Priority Populations in High Burden Areas in the Republic of South Africa under PEPFAR" (Funding Opportunity Number: CDC RFA GH19-1922) is a U.S. Centers for Disease Control and Prevention (CDC) cooperative agreement focused on accelerating progress toward HIV epidemic control in South Africa. It is framed around the reality that, even with relatively high coverage of HIV services, South Africa continues to face HIV/AIDS as a leading cause of death and has not yet met the threshold indicators associated with epidemic control. A central concern highlighted in the opportunity is the disproportionate burden among adolescent girls and young women (AGYW), particularly those ages 15-19, who experience HIV prevalence rates far higher than their male peers, with prevalence increasing sharply into the 20-24 age range. The opportunity is designed to respond to those disparities while also improving overall prevention, care, and treatment outcomes in geographic areas with the highest burden.
The program is explicitly aligned with and intended to support the Republic of South Africa's national "She Conquers" campaign for AGYW. In practice, this means applicants are expected to implement comprehensive, expanded, integrated, and sustainable HIV and TB/HIV prevention, care, and treatment programming across 27 priority high-burden districts. The NOFO emphasizes that these efforts should not be stand-alone activities; they should be integrated across the prevention-to-treatment continuum and built in a way that strengthens local systems and can be sustained. In addition to scaling interventions, the opportunity places major weight on intensive health systems strengthening (HSS) to improve prevention performance and raise service quality, recognizing that reaching epidemic control depends on reliable service delivery systems, data quality, workforce capacity, and consistent clinical and community standards.
A key feature of the opportunity is support for combination HIV prevention implemented through evidence-based interventions in 19 high-burden communities. Combination prevention generally refers to layering multiple complementary approaches so that biomedical, behavioral, and structural strategies work together, particularly for populations and places where incidence remains high. Within the scope described, recipients are expected not only to deliver interventions but also to use implementation experience to identify and refine best practices that can reduce HIV incidence at the population level in defined geographic areas. The intent is to move beyond incremental gains toward measurable changes in community-level transmission, using targeted, data-driven approaches that reflect the local epidemic and the needs of priority and key populations.
The NOFO also situates performance expectations within global epidemic-control benchmarks, specifically the UNAIDS 95-95-95 goals. This signals that funded work should contribute to increasing the proportion of people living with HIV who know their status, improving linkage and retention so that more people receive sustained antiretroviral therapy, and ensuring viral suppression at scale, because viral suppression is a cornerstone of reduced onward transmission. The opportunity further highlights the need for improved efficiency and effectiveness across both technical assistance (TA) and direct service delivery (DSD). In other words, recipients are expected to combine hands-on service expansion with targeted support to strengthen national and district capacity, so that improvements are not dependent on external implementers alone.
From an administrative standpoint, this is a discretionary funding opportunity offered by the U.S. Department of Health and Human Services, CDC (Center for Global Health), using a cooperative agreement mechanism. Cooperative agreements typically involve substantial CDC engagement, meaning recipients should anticipate close coordination with CDC and alignment with PEPFAR priorities, reporting expectations, and programmatic guidance. The CFDA number listed is 93.067. Eligibility is described as unrestricted (open to any type of entity, subject to any additional eligibility language in the full notice). The opportunity was created on September 14, 2018, with an original closing date of November 14, 2018 (applications due by 11:59 p.m. Eastern Time). The award ceiling is $20,000,000, and CDC anticipated making three awards, indicating a small number of relatively large awards intended to support substantial district and community-level impact.
Overall, the grant is aimed at accelerating epidemic control in South Africa by concentrating resources in high-burden districts and communities, prioritizing AGYW and other priority and key populations, strengthening the health system to improve quality and sustainability, and deploying evidence-based combination prevention alongside effective treatment scale-up. The expected end state is a measurable reduction in HIV incidence in targeted geographies, stronger prevention and treatment systems, and demonstrable progress toward 95-95-95 outcomes through a coordinated approach that blends direct services, technical assistance, and continuous improvement based on what works best in real-world implementation.Apply for CDC RFA GH19 1922
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Combination Prevention Solutions to Reach Epidemic Control among High Risk, Priority Populations in High Burden Areas in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Sep 14, 2018.
- Applicants must submit their applications by Nov 14, 2018 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $20,000,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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