Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required) | PAR 25 342

Opportunity Information: Apply for PAR 25 342

This NIH Notice of Funding Opportunity (PAR-25-342) supports R01 research projects that test interventions aimed at reducing health and healthcare disparities tied to non-communicable and chronic diseases (NCDs) that drive the greatest burden and mortality in Latin America and among Hispanics/Latinos in the United States. The emphasis is on practical, intervention-focused research that can improve real-world health outcomes, whether the intervention is delivered in clinical settings, through health services systems, or in communities. The NOFO is explicitly framed around interdisciplinary work, meaning applications are expected to bring together complementary expertise (for example, clinical medicine, public health, implementation science, behavioral science, epidemiology, biostatistics, health economics, health policy, and community engagement) to design, deliver, and evaluate interventions that address inequities in prevention, diagnosis, treatment, and long-term management of chronic conditions.

A central expectation is meaningful collaboration with partners in Latin America. Projects must include at least one Principal Investigator (PI) or Multiple PI (MPI) from an institution located in Latin America, reflecting NIH's intent to ensure shared leadership, local relevance, and stronger capacity for sustainable impact in the region. While the research focus is on Latin America and U.S. Hispanic/Latino populations, the design should clearly connect the intervention to disparities in health outcomes or access to quality care and show how the approach could reduce those gaps. Because the mechanism is an R01 and the NOFO states "Clinical Trial Required," applicants should plan for a study that meets NIH's definition of a clinical trial (generally involving prospective assignment of human participants to an intervention to evaluate effects on health-related outcomes). In practice, this can include individually randomized trials, cluster randomized designs, pragmatic trials embedded in health systems, and certain community-based intervention trials, as long as the study is structured to evaluate the intervention's effect on outcomes.

The opportunity is open to a wide range of applicant organizations across the United States, reflecting NIH's broad eligibility rules for grants. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled universities; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other categories listed in the announcement. The NOFO also highlights additional applicant types that NIH particularly calls out in many equity-focused programs, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

At the same time, there are important restrictions related to non-U.S. entities. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply as the applicant. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement, which typically means a U.S. applicant can include certain work performed outside the U.S. when it is justified and appropriately structured and disclosed. In other words, the applicant organization must be eligible and domestic, but the research can include international elements and partnerships, including Latin American leadership via at least one PI/MPI based at a Latin American institution, consistent with NIH policy and the NOFO's collaboration requirements.

From an administrative standpoint, this is a discretionary grant opportunity administered by the National Institutes of Health, aligned with health and education activity categories and tied to CFDA numbers 93.307, 93.313, and 93.361. The posting date is January 13, 2025, and the listed original closing date is May 7, 2027, indicating multiple potential receipt dates may fall within that window depending on NIH's application schedule for the program announcement. The award ceiling and expected number of awards are not specified in the provided summary, so applicants would typically rely on the detailed NOFO and standard NIH R01 budgeting rules to plan the scope and budget, with the understanding that NIH will evaluate alignment with the program goals, scientific merit, feasibility, and the strength of the partnership structure, including authentic engagement with Latin American institutions and other key stakeholders.

Overall, the NOFO is aimed at funding intervention trials and related intervention research that can measurably reduce disparities in chronic disease outcomes across the hemisphere by pairing rigorous study designs with collaborative, regionally grounded teams. Successful applications are likely to be those that clearly define the disparity being addressed, justify why the targeted NCD and population are high-burden and high-impact, specify a well-developed intervention with an implementation plan that fits the local context, and include an evaluation strategy that can credibly demonstrate improvements in outcomes and reductions in inequities in care or health status.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307, 93.313, 93.361.
• This funding opportunity was created on 2025-01-13.
• Applicants must submit their applications by 2027-05-07.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 25 342

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